EMPATHOGENThis is a therapeutic antibody raised against methamphetamine — not the serotonin transporter. It is shown because it is the only experimental structure with MDMA bound. No crystal or cryo-EM structure of MDMA in SERT exists. Every published image of that complex is a computational docking model, usually built into paroxetine-bound4 or serotonin-bound5 SERT.
$EMPATH · Robinhood Chain
Empathogen
A token on Robinhood Chain, named for a class of drug. This page is about the molecule that class is named after — how it is shaped, what it does at the serotonin transporter, and where the clinical research actually stands.
Curve not open
No $EMPATH contract exists yet. Any address claiming to be it right now is a scam.
MDMA · PubChem CID 1615 · 29 atoms1
- 193.24
- g/mol
- C11H15NO2
- formula
- SLC6A4
- transporter gene
- 3GM0
- pdb · 2.4 Å
What is being measured
What actually holds this molecule, and how tightly?
- the question
- A drug only works if something grips it. So: which parts of a protein take hold of MDMA, and which one holds it hardest?
- why it is hard
- Nobody has ever captured MDMA inside its real target in the brain. One picture exists of it held by anything at all — an antibody, solved in 2009 — and that is what gets measured here.2
- the answer so far
- Twelve parts touch it. Ten are flat rings gripping by shape. The tightest is not: a glutamate, 2.73 Å from the molecule's nitrogen, holding it by charge.
- 1Opens the real structure file, unchanged, from the Protein Data Bank
- 2Measures the gap between the molecule and every part of the protein
- 3Ranks them, closest first — the ones that touch rise to the top
Compute plan · 8 units · 3 online · 1 coming online · 4 queued
23.9 PFLOP/s allocated
Illustrative — how the workload would spread across dedicated hardware. The measurements below are real and run in this browser.
- ●GB200 NVL
192 GB HBM3e · online
58%
- ●B200 SXM
180 GB HBM3e · online
95%
- ●B200 SXM
180 GB HBM3e · online
60%
- ◐H200 SXM
141 GB HBM3e · coming online
- ○RTX PRO 6000
96 GB GDDR7 · queued
- ○RTX 5090
32 GB GDDR7 · queued
- ○RTX 5090
32 GB GDDR7 · queued
- ○MI300X
192 GB HBM3 · queued
Measuring now, in this browser
workers · 0 working, 0 waiting
0 queued · 0 handed out
- idle — scroll to spawn
Looking for: the closest point between the molecule and the protein
Beaten whenever it finds something tighter. The finished answer is in the table on the right — this is how far the live scan has got.
closest the scan has reached
—measuring…
- 0
- distances measured here
- 0 of them close enough to touch
- 0
- got to · of 25,465
- same for everyone, right now
every distance measured, by size
<4.58121620253030+
how close each part sits
- touching · under 4.5 Å · 0
- close · under 8 Å · 0
- nearby · under 12 Å · 0
- far · over 12 Å · 0
waiting — scroll down to start
- the molecule
- parts gripping it
- the rest of the protein
waiting
scroll to run
The full answer · all 0 parts that touch it
| part | gap Å | touches |
|---|---|---|
| no results yet | ||
Check it yourself: download 3GM0 from the Protein Data Bank and measure the distances from B41 — the MDMA in that file — to the protein around it. The file this page loads is that download, byte for byte.
The structure
The only measured structure of this molecule is not the one you would expect.
Drag to rotate · MDMA in orange, pocket residues in grey, protein fold behind
- PDB
- 3GM0
- Method
- X-ray diffraction
- Resolution
- 2.4 Å
- Deposited
- 2009-03-12
- Ligand
- B41 · S-MDMA
- Ligand atoms
- 14
The structure exists because someone was building a treatment. The protein around the molecule is a single-chain antibody fragment developed as a candidate therapeutic against methamphetamine — the idea being to bind the drug and hold it before it reaches the brain. It was crystallised with two substrates to see how it grips them, and MDMA was the second.3
So what you are looking at is a molecule held in something designed to capture it, rather than in the transporter it acts on. The pocket is not SERT and the geometry is not SERT's. What it does show, measured rather than modelled, is the molecule's own conformation — which ring sits where, and how the amine presents.
That gap is worth stating plainly, because it is the interesting part: one of the most studied recreational compounds of the last forty years has never had its complex with its primary target solved experimentally.
- Contains
- Single-chain antibody Fv (scFv), one chain
- Ordered waters
- 77
- Ligand formula
- C11 H15 N O2
Mechanism
Substrate, not blocker.
The common antidepressants — SSRIs — plug the transporter and stop it working. Serotonin builds up outside the cell because it cannot get back in. The pump is blocked, but it is still pointing the same way.
MDMA does something else. The transporter picks it up as if it were serotonin and carries it inside — and in doing so it starts running the other way. Serotonin gets pushed out of the cell instead of pulled in.6 The pump does not stop. It runs backwards.
That is the difference worth knowing, and it is why this class of drug is named after what it does rather than what it binds to.
- Transporter
- SERT · Serotonin transporter
- Gene
- SLC6A4
Diagram of which way the transporter moves serotonin. Not a microscope image
The molecule
It comes in two mirror-image forms. Only one of them has ever been photographed.
MDMA comes in two mirror-image forms — like a left and a right hand, same parts, not interchangeable. The one called S carries the stimulant and empathy-like effect; the one called R leans more hallucinogenic.8
The ligand in 3GM0 is the S enantiomer — the half the word empathogen refers to.2 The trials used both halves mixed together, which is how the compound is normally made.7
So the only form anyone has managed to capture is exactly the half this token is named after, while the thing actually tested on patients was the mixture.
| Formula | C11H15NO2 |
|---|---|
| Molecular mass | 193.24 g/mol |
| IUPAC name | 1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine |
| As crystallised | (2S)-1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine |
| PubChem CID | 16151 |
| Chiral centres | 1 |
| Atoms · bonds | 29 · 30 |
| Primary target | Serotonin transporter (SERT), SLC6A4 |
Read from the PubChem and RCSB APIs, 2026-09-15
The record
Where the clinical research actually stands.
MDMA-assisted therapy is not an approved medicine. It has been through phase 3, been refused, and been resubmitted. That is the whole position, and it is worth stating without varnish.
- 2023Phase 3 result publishedMDMA-assisted therapy for moderate to severe PTSD, randomised and placebo-controlled, reported in Nature Medicine. Racemic MDMA.7
- August 2024FDA declines approvalA Complete Response Letter: the application could not be approved on the data submitted, and the agency asked for an additional phase 3 trial.9
- Late 2024Sponsor restructuresLykos Therapeutics reduced its workforce by roughly 75% and reorganised around continued engagement with the FDA.10
- August 2026ResubmittedResilient Pharmaceuticals — formerly MAPS PBC, then Lykos — resubmitted the NDA without running a new phase 3, addressing the agency through reanalysis and reporting instead. A fresh review cycle opened under the FDA’s newly finalised psychedelic trial guidance.12
Status, plainly
Not approved by the FDA. In the United States the only lawful routes of access are enrolment in a clinical trial and FDA Expanded Access for individual patients.9 Nothing on this page is medical advice, and this project has no connection to any trial, sponsor or institution named above. They are cited because they are the published record, not because they are affiliated.13
The token
$EMPATH
EMPATHOGEN launches on pons, the launchpad carrying most of Robinhood Chain. pons V2 mints the entire supply straight into a constant-product bonding curve — trades go against that curve rather than a DEX until it takes in its graduation threshold, at which point the token graduates into a permanently locked, full-range Uniswap v4 pool under a shared hook.15
The supply figure below is not a choice we made. Every pons V2 launch mints exactly that amount.
- 1The curve opensAll 1,000,000,000 $EMPATH is minted straight into a bonding curve. There is no presale, no team allocation to unlock and no liquidity to add — the curve is the market from the first block.
- 2It trades against the curvePrice is set by the curve, not by an order book, so early and late buyers are on the same published schedule. Every trade is on Robinhood Chain and visible on the explorer.
- 3It graduatesOnce the curve takes in its threshold, the token moves into a permanently locked full-range Uniswap v4 pool. Locked means the liquidity cannot be pulled.
Curve not open
| Ticker | $EMPATH |
|---|---|
| Supply | 1,000,000,000 |
| Contract | none yet — see note below |
| Chain | Robinhood Chain14 |
| Chain ID | 4663 · 0x1237 |
| Gas | ETH |
| Stack | Arbitrum L2 on Ethereum |
| Explorer | blockscout ↗ |
Watch out
No $EMPATH contract exists yet, and this page will show the real address here the moment it does. If you see an address anywhere claiming to be $EMPATH before then, it is a scam.